Vermox is a broad spectrum anthelmintic action. Vermox (generic name: mebendazole) is active against Enterobios vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides sterooralis, Taenia spp. Prevents the formation of cellular tubulin in helminths, thus violating the utilization of glucose and inhibits the formation of ATP.
After oral administration of mebendazole practically not absorbed. A small part of mebendazole, has gotten into the blood by 90% bound to plasma proteins. Metabolized in the liver. Almost completely excreted in the feces.
INDICATIONS: Helminthiasis, hookworm, strongyloidiasis, trihofatselez, teniasis mixed helminth infections.
APPLICATION: When enterobioze prescribe a single dose of 100 mg. To prevent re-infestation receiving mebendazole repeated after 2 and 4 weeks at the same dose. Recommend the simultaneous treatment of all family members.
When ascariasis, trihotsefaleze, hookworm, or mixed infections administered 100 mg 2 times a day (morning and evening) for 3 days. The above dosages administered to both adults and children.
When teniasis strongiloidoze and adults are encouraged to take 200 mg for children – 100 mg 2 times a day for 3 days.
CONTRAINDICATIONS: Hypersensitivity to mebendazole.
SIDE EFFECTS: In the case of massive infestation and rapid removal of worms sometimes observed transient abdominal pain, diarrhea, allergic reactions (rash, urticaria, angioedema).
SPECIAL NOTES: The use of mebendazole is not required dieting, laxative use.
During pregnancy, especially in the I trimester, mebendazole should be used only if the alleged therapeutic effect of the potential risk. If necessary, the appointment of mebendazole during lactation breastfeeding should be discontinued.
Children under the age of 1 year is prescribed only if against helminthic infestations significantly worse slows down the digestive process and physical development.
INTERACTION: co-administration with cimetidine can enhance the effect of mebendazole by inhibiting its metabolism in the liver and increase the concentration in blood plasma.
OVERDOSE: manifested by nausea, vomiting, diarrhea, abdominal pain. When using mebendazole in high doses for long time there has also cases reversible liver dysfunction or of hepatitis neutropenia. No specific antidote. Recommended gastric lavage, administration of activated charcoal.